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HLA and Leukemia Associations
M.Tevfik Dorak, MD, PhD
PowerPoint presentation on MHC
& Leukemia Associations in Humans
Here you will find
a list of my published papers on the immunogenetics of leukaemia. Also
relevant are the following sites:
Abstracts of our Current Research
Frequently Asked Questions about HLA-DR53 and Leukemia HLA-DR53 Fact File
Abstracts of Other Molecular HLA Studies in Childhood ALL
Statistical Analysis in
HLA and Disease Association Studies
Full Publication List with
Abstracts (may take few minutes)
* * *
HLA and LEUKEMIA
LATEST
Conserved
Extended Haplotypes of the Major Histocompatibility Complex: Further
Characterization
Commentary:
HFE H63D variant and leukemia
Leukemia & Lymphoma (in press)
Hemochromatosis Gene
in Childhood Leukemia [HuGE Review]
M
Tevfik Dorak, Alan K Burnett, Mark Worwood
Genetics in Medicine 2005;7(3):159-68 (Full-text)
* * *
1992
Major Histocompatibility
Complex, t-Complex, and Leukemia
Cancer
Causes & Control 3:273-282)
MHC has a recessive
influence in the development of leukaemia and abortions
Leukemia
susceptibility genotype should have a protective mechanism to escape natural
selection
In analogy to the
mouse t-complex, this protective mechanism may be TRD
Haplotypes showing
TRD may be associated with leukaemia in homozygous form
Human
MHC Contains Several Leukemia Susceptibility Genes
(Dorak et al. Leuk & Lymph 12:211-222)
No
HLA/MHC allele has any association with CML
HLA-DR53
haplotypes show TRD in controls (kidney transplant patients’ families)
Homozygosity
for HLA-DR53 accelerates the development of CML
(similar
to the interactive influence of -cross-reactive- H-2k in mice)
Homozygous MHC Genotypes and Longevity
(Dorak et al. Hum Hered 44:271-278)
Homozygosity
for HLA-DR53 is increased in young males and shows a significant decrease with
age
Homozygosity
for the HLA-DR53 - HSP70*L haplotype shows difference between the gender groups
Molecular
Mimicry of an HLA-DR53 Epitope by Viruses [letter]
(Dorak & Burnett. Immunol Today 15:138-139)
HVR3-encoded
epitope of HLA-DR53 is mimicked by viruses
(7/7
amino acids [LLERRRA] by adenovirus & EBV)
Nature
of HLA-Associated Predisposition to Childhood ALL
(Dorak et al. Leukemia 9:875-878)
Homozygosity
for HLA-DR53 is increased in boys with ALL (compared to the adult frequency)
[see
also Dorak et al. 1999a, 2000, 2002b]
Influence
of the MHC on Age at Onset of CLL
(Dorak et al. Int J Cancer 65:134-139)
HLA
and Hodgkin's disease [letter]
(Dorak et al. Leukemia 1996;10:1671-2)
Criticism
of an HLA-disease association study in terms of design and data analysis
The
Implications for Childhood Leukemia of Infection with Adenovirus [Opinion]
(Dorak MT. Trends Microbiol 4:60-63)
(PDF)
The
long-suspected viral link in childhood ALL may be adenovirus
[as
a promoter of pre-existing mutant clones that have arisen spontaneously]
Role
of the Major Histocompatibility Complex in the Genetics of Human Leukemia
[Review]
(Dorak
MT. Turkish Journal of Medical Sciences 1996;26:119-123)
HLA
and Hodgkin's disease: Reply to Taylor and Gokhale [letter]
(Dorak et al. Leukemia 11:892-893)
A
mini-review of our data on HLA-DR53 association in leukaemias
A
Sex-Specific Difference in Homozygosity for HLA-DR53 in Newborns
(Sunguroglu A et al. Turk J Ped
1998;40:211-6)
Unravelling
an HLA-DR Association in Childhood Acute Lymphoblastic Leukemia
(Dorak et al. Blood 1999a;94:694-700; full-text)
(Dorak et al. Blood 1999b;94:3957-8; full-text)
A
Search for a Leukaemia Susceptibility Gene in the HLA Complex ..
Both
are presented as abstracts.
Hemochromatosis Gene in
Leukemia and Lymphoma
(Dorak,
Burnett, Worwood, 2002a, Leukemia & Lymphoma 2002;43(3):467-477; PubMed)
A Male-Specific
Increase in the HLA-DRB4 (DR53) Frequency in High-Risk and Relapsed Childhood
ALL
(Dorak
et al, 2002b, Leukemia Research 2002;26(7):651-6; PubMed)
Increased
Heterozygosity for MHC Class II Lineages in Newborn Males
(Dorak
et al, 2002c, Genes & Immunity 2002;3(5):263-9, PubMed)
HLA System Affects the
Age-at-Onset in Chronic Myeloid Leukemia
Medline search for papers by Dorak MT
Great
North Run in Aid of Children with Leukemia